Glycolysis GlycolysisGlycolysis is the primary pathway for anaerobic degradation of D-glucopyranoses and other D-hexopyranoses. It is probably universal among organisms: certainly the enzymes which catalyze the pathway's reactions are among the most conserved (and therefore presumably most ancient) among proteins.
This representation of glycolysis is faithful to the
topology of the pathway as currently represented in Atropos.
As written, each reaction summarizes its net biochemistry for the enzymes present in
E. coli. The spontaneous hydrolysis of Mg++ ATP (reaction 153) is also included.
Because
CONCORD
does not permit computation of compounds with bound ions, the pages for ATP and ADP are
used. The compounds are shown as colored disks and the
reactions
as
numbered heptagons. Pink arcs indicate a compound is a substrate
of the reaction, while blue arcs indicate the metabolite is a product. The numbers
correspond to the serial numbers of the reactions in Atropos. For further
information on compounds or reactions, click on each node.
The figure bears a family resemblance to Peter Murray-Rust's
Collaborative Clickable Biology
:
my thanks to
Peter and to
Henry Rzepa and
Benjamin Whitaker
for teaching us how to animate gif images.
Copyright 1993, 1994 by the Institute for Biomedical Computing, Washington University. All Rights Reserved.
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